MICRORHEOLOGY OF ERYTHROCYTES IN ARTERIAL HYPERTENSION AND DYSLIPIDEMIA WITH A COMPLEX HYPOLIPIDEMIC TREATMENT

Abstract

Aim. To evaluate the applicability of a complex of non-medication treatment and simvastatin in hypertension and dyslipidemia management, from perspective of disordered rheological properties of erythrocytes.Material and methods. Totally, 55 hypertensive patients included, with 1-2 grade of hypertension and IIb type dyslipidemia, risk 4, middle age. Controls were 26 healthy persons of the same age. The biochemical, hematological and statistical methods were applied.Results. Simultaneous application of non-drug treatment and simvastatin in arterial hypertension with dyslipidemia does make optimal the lipid profile of plasma in 12 weeks, and lipid content of erythrocytes, lipids peroxidation of the liquid blood and red blood cells — in 6 weeks. Prescription of non-drug management and simvastatin to the studied patients does normalize their cytoarchitectonics and spontaneous erythrocyte aggregation in 6 weeks of treatment, having retained the results for at least the following 98 weeks of treatment.Conclusion. Complex application of non-medication treatment and simvastatin does normalize erythrocyte microrheologic properties for 6 weeks in hypertension patients with dyslipidemia.

Keywords

• arterial hypertension
• dyslipidemia
• aggregation
• cytoarchitectonics
• erythrocytes
• simvastatin
• hypolipidemic diet
• exercises