Utilizing Drosophila Melanogaster in Alzheimer's Disease Research:Applications and Insights

Huiying Ma; Xiaoyun Zhang; Liyuan Zhang; Fangyu Li; Xinran Li; Mingxue Zhu; Limin Yang

doi:10.3969/j.issn.1674-7593.2024.02.018

Guoji laonian yixue zazhi (Mar 2024)

Utilizing Drosophila Melanogaster in Alzheimer's Disease Research:Applications and Insights

Huiying Ma,
Xiaoyun Zhang,
Liyuan Zhang,
Fangyu Li,
Xinran Li,
Mingxue Zhu,
Limin Yang

Affiliations

Huiying Ma: Department of Human Anatomy and Histology and Embryology, School of Medicine, Dalian University, Dalian 116622
Xiaoyun Zhang: Department of Human Anatomy and Histology and Embryology, School of Medicine, Dalian University, Dalian 116622
Liyuan Zhang: Department of Human Anatomy and Histology and Embryology, School of Medicine, Dalian University, Dalian 116622
Fangyu Li: Department of Human Anatomy and Histology and Embryology, School of Medicine, Dalian University, Dalian 116622
Xinran Li: Department of Human Anatomy and Histology and Embryology, School of Medicine, Dalian University, Dalian 116622
Mingxue Zhu: Chronic DiseaseResearch Center of Dalian, Dalian 116622
Limin Yang: Department of Human Anatomy and Histology and Embryology, School of Medicine, Dalian University, Dalian 116622

DOI: https://doi.org/10.3969/j.issn.1674-7593.2024.02.018
Journal volume & issue: Vol. 45, no. 02
pp. 221 – 224

Abstract

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Alzheimer′s disease(AD) is a widely recognized chronic neurodegenerative condition.Drosophila, with its well-defined genetic structure, straightforward experimental methodologies, and the presence of human disease-related genes or highly similar homologous genes, serves as an advantageous model organism.The utilization of Drosophila′s renowned Galactose-regulated Upstream Promoter Element 4-Upstream Activating Sequence(GAL4-UAS) system has led to the development of various AD models.These models facilitate the exploration of AD′s molecular mechanisms and the advancement of drug discovery efforts.This paper reviews the foundational principles, methodologies, and diverse applications of different AD Drosophila models, offering insights and innovative approaches for AD research utilizing Drosophila.

Published in Guoji laonian yixue zazhi

ISSN: 1674-7593 (Print)
Publisher: Editorial Office of International Journal of Geriatrics
Country of publisher: China
LCC subjects: Medicine: Internal medicine: Special situations and conditions: Geriatrics
Website: https://gwll.publish.founderss.cn/homeNav?lang=en

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