Application of PSMA PET/CT Specific Molecular Imaging in Diagnosis of Non-prostate Cancer

LIU Teli; LIU Chen; ZHANG Yuqi; DENG Yujiao; ZHU Hua; YANG Zhi

doi:10.3971/j.issn.1000-8578.2019.19.0356

Zhongliu Fangzhi Yanjiu (Nov 2019)

Application of PSMA PET/CT Specific Molecular Imaging in Diagnosis of Non-prostate Cancer

LIU Teli,
LIU Chen,
ZHANG Yuqi,
DENG Yujiao,
ZHU Hua,
YANG Zhi

Affiliations

LIU Teli: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China
LIU Chen: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China
ZHANG Yuqi: Department of Clinical Medicine, Clinical Medical College, Xuzhou Medical University, Xuzhou 221004, China
DENG Yujiao: Medical Imaging, Second Clinical College of Chongqing Medical University, Chongqing 401331, China
ZHU Hua: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China
YANG Zhi: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China

DOI: https://doi.org/10.3971/j.issn.1000-8578.2019.19.0356
Journal volume & issue: Vol. 46, no. 11
pp. 1022 – 1025

Abstract

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Prostate specific membrane antigen(PSMA) is a glutamate carboxypeptidase Ⅱ secreted by the epithelial cells of prostate gland. PSMA is over-expressed in the cells of prostate cancer and metastases, and also positively expressed in the tumor-related neovascular endothelial cells. Therefore, more than twenty PSMA-targeted probes had been used for the diagnosis and therapy of prostate cancer. This article reviews the expression of PSMA in non-prostate cancer and the clinical application of PSMA-PET/CT specific probes in detecting non-prostate cancer, to expand the clinical application of novel PSMA-targeted PET probes in the diagnosis of tumors.

Published in Zhongliu Fangzhi Yanjiu

ISSN: 1000-8578 (Print)
Publisher: Magazine House of Cancer Research on Prevention and Treatment
Country of publisher: China
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.zlfzyj.com

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