Thieno[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents

Abstract

Thienopyrimidines are fused heterocyclic ring systems; structurally resemble purines, exerting pharmacological potential in different aspects. They are known to play a crucial role in various disease conditions. Thieno[2,3-d]pyrimidine derivatives have been explored for their inhibitory activities towards various protein kinase enzymes. The present review is a compilation on chemical synthesis and biological anticancer significance, via inhibition of specific protein kinase enzymes, including structure–activity relationships of thieno[2,3-d]pyrimidines derivatives reported to date.

Keywords

• Kinase inhibitors
• Thieno[2,3-d]pyrimidine
• Synthetic strategy
• SAR