Frontiers in Chemistry (Nov 2019)

A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H2S-Activated Second Near-Infrared Emission for Bioimaging

  • Rongchen Wang,
  • Wei Gao,
  • Jie Gao,
  • Ge Xu,
  • Tianli Zhu,
  • Xianfeng Gu,
  • Chunchang Zhao

DOI
https://doi.org/10.3389/fchem.2019.00778
Journal volume & issue
Vol. 7

Abstract

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Real-time and accurate detection of endogenous hydrogen sulfide is of great biomedical significance. Here, a FRET-based fluorescent probe for ratiometric detection of H2S was designed to comprise an AIE luminophore TPE as an energy donor and a monochlorinated BODIPY dye as an energy acceptor and H2S-responsive site. Such a designed probe showed H2S-dependent ratiometric and light-up NIR-II emission, enabling accurate imaging of H2S-rich cancer cells and identification of H2S-rich tumors with high resolution.

Keywords