Nature Communications (Jun 2020)
Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients
- Chek Meng Poh,
- Guillaume Carissimo,
- Bei Wang,
- Siti Naqiah Amrun,
- Cheryl Yi-Pin Lee,
- Rhonda Sin-Ling Chee,
- Siew-Wai Fong,
- Nicholas Kim-Wah Yeo,
- Wen-Hsin Lee,
- Anthony Torres-Ruesta,
- Yee-Sin Leo,
- Mark I-Cheng Chen,
- Seow-Yen Tan,
- Louis Yi Ann Chai,
- Shirin Kalimuddin,
- Shirley Seah Gek Kheng,
- Siew-Yee Thien,
- Barnaby Edward Young,
- David C. Lye,
- Brendon John Hanson,
- Cheng-I Wang,
- Laurent Renia,
- Lisa F. P. Ng
Affiliations
- Chek Meng Poh
- Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis
- Guillaume Carissimo
- Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis
- Bei Wang
- Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis
- Siti Naqiah Amrun
- Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis
- Cheryl Yi-Pin Lee
- Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis
- Rhonda Sin-Ling Chee
- Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis
- Siew-Wai Fong
- Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis
- Nicholas Kim-Wah Yeo
- Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis
- Wen-Hsin Lee
- Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis
- Anthony Torres-Ruesta
- Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis
- Yee-Sin Leo
- National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng
- Mark I-Cheng Chen
- National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng
- Seow-Yen Tan
- Department of Infectious Diseases, Changi General Hospital
- Louis Yi Ann Chai
- Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng
- Shirin Kalimuddin
- Department of Infectious Diseases, Singapore General Hospital
- Shirley Seah Gek Kheng
- Biological Defence Program, DSO National Laboratories
- Siew-Yee Thien
- Department of Infectious Diseases, Singapore General Hospital
- Barnaby Edward Young
- National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng
- David C. Lye
- National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng
- Brendon John Hanson
- Biological Defence Program, DSO National Laboratories
- Cheng-I Wang
- Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis
- Laurent Renia
- Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis
- Lisa F. P. Ng
- Singapore Immunology Network, Agency of Science, Technology and Research, Immunos, Biopolis
- DOI
- https://doi.org/10.1038/s41467-020-16638-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 7
Abstract
Characterisation of the human antibody response to SARS-CoV-2 can help the design of serological tests and vaccines. Here, the authors identify two linear epitopes in SARS-CoV-2 spike protein that elicit neutralising antibodies in several patients and could thus be useful for serology and vaccine development.
