Suppression of matrix metalloproteinase-9 production from neutrophils by a macrolide antibiotic, roxithromycin, in vitro

Ken-Ichi  Kanai; Kazuhito  Asano; Tadashi  Hisamitsu; Harumi  Suzaki

doi:10.1080/09629350400008810

Mediators of Inflammation (Jan 2004)

Suppression of matrix metalloproteinase-9 production from neutrophils by a macrolide antibiotic, roxithromycin, in vitro

Ken-Ichi Kanai,
Kazuhito Asano,
Tadashi Hisamitsu,
Harumi Suzaki

Affiliations

Ken-Ichi Kanai: Department of Otolaryngology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
Kazuhito Asano: Department of Physiology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
Tadashi Hisamitsu: Department of Physiology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
Harumi Suzaki: Department of Otolaryngology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

DOI: https://doi.org/10.1080/09629350400008810
Journal volume & issue: Vol. 13, no. 5-6
pp. 313 – 319

Abstract

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BACKGROUND: Macrolide antibiotics such as erythromycin and roxithromycin (RXM) have an anti-inflammatory effect that may account for their clinical benefit in the treatment of chronic airway inflammatory diseases. However, the precise mechanism of this anti-inflammatory effect is not well understood.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

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