Nature Communications (Oct 2018)
Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers
- Yan Zhang,
- Dayong Zheng,
- Ting Zhou,
- Haiping Song,
- Mohit Hulsurkar,
- Ning Su,
- Ying Liu,
- Zheng Wang,
- Long Shao,
- Michael Ittmann,
- Martin Gleave,
- Huanxing Han,
- Feng Xu,
- Wangjun Liao,
- Hongbo Wang,
- Wenliang Li
Affiliations
- Yan Zhang
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Dayong Zheng
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Ting Zhou
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Haiping Song
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Mohit Hulsurkar
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Ning Su
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Ying Liu
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Zheng Wang
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Long Shao
- Department of Pathology and Immunology, Baylor College of Medicine, and Michael E. DeBakey VAMC
- Michael Ittmann
- Department of Pathology and Immunology, Baylor College of Medicine, and Michael E. DeBakey VAMC
- Martin Gleave
- Department of Urologic Sciences and Vancouver Prostate Centre, University of British Columbia
- Huanxing Han
- Department of Pharmacy, Changzheng Hospital
- Feng Xu
- Department of Pharmacy, Fengxian Hospital, Southern Medical University
- Wangjun Liao
- Department of Medical Oncology, Nanfang Hospital, Southern Medical University
- Hongbo Wang
- Department of Gynaecology and Obstetrics, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
- Wenliang Li
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- DOI
- https://doi.org/10.1038/s41467-018-06177-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
Neuroendocrine prostate cancers are very difficult to treat and often arise after androgen-deprivation therapy. Here the authors show that ADT activates CREB that acts by increasing EZH2 activity to promote neuroendocrine differentiation in prostate cancer, providing alternative avenues for therapy.
