Lung abscess by Fusobacterium nucleatum and Streptococcus spp. co-infection by mNGS: A case series

Abstract

The aim of this article was to employ shotgun mNGS for pathogen diagnosis in three patients with lung abscesses. The pleural fluid or bronchoalveolar lavage fluid from patients was sent to traditional culture and the shotgun mNGS test. Laboratory culture tested negative and shotgun mNGS analysis revealed a co-infection caused by Fusobacterium nucleatum and Streptococcus spp. After standard treatment of co-infection, patients gradually improved and were discharged. This figure is drawn by Figdraw.

Keywords

• co-infection
• fusobacterium nucleatum
• lung abscess
• shotgun metagenome next-generation sequencing
• streptococcus spp.