Nature Communications (Mar 2021)
A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport
- Adham Safieddine,
- Emeline Coleno,
- Soha Salloum,
- Arthur Imbert,
- Abdel-Meneem Traboulsi,
- Oh Sung Kwon,
- Frederic Lionneton,
- Virginie Georget,
- Marie-Cécile Robert,
- Thierry Gostan,
- Charles-Henri Lecellier,
- Racha Chouaib,
- Xavier Pichon,
- Hervé Le Hir,
- Kazem Zibara,
- Florian Mueller,
- Thomas Walter,
- Marion Peter,
- Edouard Bertrand
Affiliations
- Adham Safieddine
- Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS
- Emeline Coleno
- Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS
- Soha Salloum
- Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS
- Arthur Imbert
- MINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology
- Abdel-Meneem Traboulsi
- Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS
- Oh Sung Kwon
- Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University
- Frederic Lionneton
- BioCampus Montpellier
- Virginie Georget
- BioCampus Montpellier
- Marie-Cécile Robert
- Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS
- Thierry Gostan
- Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS
- Charles-Henri Lecellier
- Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS
- Racha Chouaib
- Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS
- Xavier Pichon
- Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS
- Hervé Le Hir
- Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University
- Kazem Zibara
- ER045, PRASE, and Biology Department, Faculty of Sciences-I, Lebanese University
- Florian Mueller
- Imaging and Modeling Unit, Institut Pasteur, UMR 3691 CNRS, C3BI USR 3756 IP CNRS
- Thomas Walter
- MINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology
- Marion Peter
- Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS
- Edouard Bertrand
- Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS
- DOI
- https://doi.org/10.1038/s41467-021-21585-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 21
Abstract
Centrosomes function as microtubule organizing centers where several mRNAs accumulate. By employing high-throughput single molecule FISH screening, the authors discover that 8 human mRNAs localize to centrosomes with unique cell cycle dependent patterns using an active polysome targeting mechanism.
