Distinctively different predictors for long‐term outcomes between responders and nonresponders who underwent cardiac resynchronization therapy

Abstract

Abstract Background It is common to develop heart failure (HF) events even in respondents to cardiac resynchronization therapy (CRT) during a long‐term observation period. We investigated the predictors for long‐term outcome in responders in comparison with nonresponders in patients diagnosed with HF along with implanted CRT. Methods We enrolled 133 consecutive patients (mean age, 70 ± 10 years; 72 males) implanted with CRT from April 2010 to July 2019. Accurate follow‐up information (mean follow‐up period, 983 ± 801 days) was obtained from 66 responders and 53 nonresponders. Results Kaplan‐Meier event‐free curves showed that major adverse cerebral and cardiovascular event (MACCE)‐free ratio was significantly lower as the stage of renal function progresses (log rank, 19.5; P 44 mL/min/1.73 m2) group than in the depressed group (log rank, 20.29; P < .0001). Conclusion We demonstrate that the factors for MACCEs during long follow‐up periods were distinctively different between responders and nonresponders. Patients with depressed e‐GFRs are suggested to have poor prognosis even if they are responders to CRT.

Keywords

• cardiac resynchronization therapy
• heart failure
• long‐term outcome
• renal function
• responder