Experience with the successful use of topical beta-adrenoblockers in the treatment of infantile hemangiomas: a clinical case and review of the literature

Abstract

Background. Infantile (infantile) hemangiomas are benign vascular tumors found predominantly in the pediatric population. Its presence can lead not only to aesthetic discomfort of the child, but also to gross functional disorders. The etiology of infantile hemangiomas is not fully understood. It is assumed that the development of this neoplasm is based on abnormal proliferation of endothelial cells with disruption of the architectonics of blood vessels due to mutation of genes responsible for the processes of tissue proliferation, or as a consequence of antenotal and/or perinatal hypoxia. Despite the fact that in some cases infantile hemangiomas can resolve spontaneously, the question of their therapy is relevant and is considered in relation to each patient individually. To date, the first line of therapy is the administration of the beta-adrenoblocker propranolol, with marked clinical improvement, but possible development of a number of side effects. Therapy is initiated as early as possible, that is, during the proliferative phase of infantile hemangioma development. The chosen method of treatment should be as effective as possible and should not lead to serious complications and the development of side effects. Since there is no unified approach to the management of such patients in the literature, it is necessary to continue searching for other methods of infantile hemangioma treatment depending on the clinical and morphologic course of the disease.Conclusion. This article presents a clinical case of infantile hemangioma and the results of topical beta-blocker use as an alternative treatment method to reduce the risk of side effects of the beta-adrenoblocker group of drugs.

Keywords

• infantile hemangioma
• b-adrenoblockers
• timolol