PLoS ONE (Jan 2021)

Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study.

  • Ezequiel Cordova,
  • Analia Mykietiuk,
  • Omar Sued,
  • Lautaro De Vedia,
  • Natalia Pacifico,
  • Matias H Garcia Hernandez,
  • Natalia M Baeza,
  • Franco Garibaldi,
  • Maria Fernanda Alzogaray,
  • Rosa Contreras,
  • Lucrecia Soler Puy,
  • Pablo G Scapellato,
  • Laura Barcelona,
  • Mariana L Golikow,
  • Maria Florencia Piñeiro,
  • Hugo J Miño,
  • Maria Fernanda Consalvo,
  • Corina Nemirovsky,
  • Marisa Sanchez,
  • Myrna Cabral,
  • Lucia Lamponi Tappata,
  • Mariano Blasco,
  • Jamile Ballivian,
  • Gustavo Lopardo,
  • Martin E Stryjewski,
  • ECCOVID study group

DOI
https://doi.org/10.1371/journal.pone.0258260
Journal volume & issue
Vol. 16, no. 10
p. e0258260

Abstract

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BackgroundClinical features and outcomes of SARS-CoV-2 infections diverge in different countries. The aim of this study was to describe clinical characteristics and outcomes in a cohort of patients hospitalized with SARS-CoV-2 in Argentina.MethodsMulticenter prospective cohort study of ≥18 years-old patients with confirmed SARS-CoV-2 infection consecutively admitted to 19 hospitals in Argentina. Multivariable logistic regression models were used to identify variables associated with 30-day mortality and admission to intensive care unit (ICU).ResultsA total of 809 patients were analyzed. Median age was 53 years, 56% were males and 71% had at least one comorbidity. The most common comorbidities were hypertension (32%), obesity (23%) and diabetes (17%). Disease severity at admission was classified as mild 25%, moderate 51%, severe 17%, and critical 7%. Almost half of patients (49%) required supplemental oxygen, 18% ICU, and 12% invasive ventilation. Overall, 30-day mortality was 11%. Factors independently associated with ICU admission were male gender (OR 1.81; 95%CI 1.16-2.81), hypertension (OR 3.21; 95%CI 2.08-4.95), obesity (OR 2.38; 95%CI 1.51-3.7), oxygen saturation ≤93% (OR 6.45; 95%CI 4.20-9.92) and lymphopenia (OR 3.21; 95%CI 2.08-4.95). Factors independently associated with 30-day mortality included age ≥60 years-old (OR 2.68; 95% CI 1.63-4.43), oxygen saturation ≤93% (OR 3.19; 95%CI 1.97-5.16) and lymphopenia (OR 2.65; 95%CI 1.64-4.27).ConclusionsThis cohort validates crucial clinical data on patients hospitalized with SARS-CoV-2 in Argentina.