Prognostic Evaluation of C-reactive Protein/Serum Albumin Ratio in Elderly Patients with Acute Myeloid Leukemia

Abstract

Objective To investigate the value of C-reactive protein to serum albumin ratio ( CAR ) in evaluating the prognosis of elderly patients with acute myeloid leukemia. Methods A retrospective analysis was performed on 84 elderly patients with non-M3 acute myeloid leukemia diagnosed in the Affiliated Hospital of Xuzhou Medical University from February 2018 to December 2022. According to the ROC curve, the optimal cut-off point of CAR was determined, and the patients were divided into a low CAR group and high CAR group. The differences of clinical indexes between the groups were compared. The survival curve was drawn by the Kaplan-Meier method, and the prognostic factors were analyzed by the COX proportional hazard regression model. Results According to ROC, the AUC of CAR was 0.870 (95% CI: 0.788 - 0.953, P 0.370 were in the high CAR group. In the high CAR group, the C-reactive protein value was higher (P < 0.05), and the serum albumin value was lower (P < 0.05) . The patients in the low CAR group were more likely to achieve the first complete remission after induction chemotherapy (P < 0.05) . The overall survival and progression-free survival of the low CAR group were better than those of the high CAR group, and the differences were statistically significant (P < 0.05) . COX proportional hazard regression model showed that CAR was an independent risk factor affecting the prognosis of elderly patients with acute myeloid leukemia (P < 0.05) . Conclusion The higher CAR value suggests that the prognosis of elderly patients with non-M3 acute myeloid leukemia is worse, and CAR may be an effective marker for the prognosis rating of such patients.

Keywords

• acute myeloid leukemia
• c-reactive protein to serum albumin ratio
• prognosis