Structure of the cohesin loader Scc2

William C. H. Chao; Yasuto Murayama; Sofía Muñoz; Andrew W. Jones; Benjamin O. Wade; Andrew G. Purkiss; Xiao-Wen Hu; Aaron Borg; Ambrosius P. Snijders; Frank Uhlmann; Martin R. Singleton

doi:10.1038/ncomms13952

Nature Communications (Jan 2017)

Structure of the cohesin loader Scc2

William C. H. Chao,
Yasuto Murayama,
Sofía Muñoz,
Andrew W. Jones,
Benjamin O. Wade,
Andrew G. Purkiss,
Xiao-Wen Hu,
Aaron Borg,
Ambrosius P. Snijders,
Frank Uhlmann,
Martin R. Singleton

Affiliations

William C. H. Chao: Structural Biology of Chromosome Segregation Laboratory, The Francis Crick Institute
Yasuto Murayama: Chromosome Segregation Laboratory, The Francis Crick Institute
Sofía Muñoz: Chromosome Segregation Laboratory, The Francis Crick Institute
Andrew W. Jones: Protein Analysis and Proteomics Platform, The Francis Crick Institute
Benjamin O. Wade: Structural Biology of Chromosome Segregation Laboratory, The Francis Crick Institute
Andrew G. Purkiss: Structural Biology of Chromosome Segregation Laboratory, The Francis Crick Institute
Xiao-Wen Hu: Structural Biology of Chromosome Segregation Laboratory, The Francis Crick Institute
Aaron Borg: Protein Analysis and Proteomics Platform, The Francis Crick Institute
Ambrosius P. Snijders: Protein Analysis and Proteomics Platform, The Francis Crick Institute
Frank Uhlmann: Chromosome Segregation Laboratory, The Francis Crick Institute
Martin R. Singleton: Structural Biology of Chromosome Segregation Laboratory, The Francis Crick Institute

DOI: https://doi.org/10.1038/ncomms13952
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

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The cohesin complex maintains genome integrity by ensuring correct sister-chromatid segregation during mitosis and meiosis. Here, Chaoet al. present a pseudo-atomic model of the full-length Scc2–Scc4 cohesin loader complex and reveal key Scc2 surfaces crucial for cohesin loading.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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