The impact of copper on bone metabolism

Zihan Zhang; Huixue Tang; Tingting Du; Di Yang

Journal of Orthopaedic Translation (Jul 2024)

The impact of copper on bone metabolism

Zihan Zhang,
Huixue Tang,
Tingting Du,
Di Yang

Affiliations

Zihan Zhang: Liaoning Provincial Key Laboratory of Oral Disease, Department of Endodontics, School and Hospital of Stomatology, China Medical University, Shenyang, 110002, China
Huixue Tang: Liaoning Provincial Key Laboratory of Oral Disease, Department of Endodontics, School and Hospital of Stomatology, China Medical University, Shenyang, 110002, China
Tingting Du: Corresponding author. School of Stomatology, Shenyang Medical College, Shenyang, 110100, China.; Liaoning Provincial Key Laboratory of Oral Disease, Department of Endodontics, School and Hospital of Stomatology, China Medical University, Shenyang, 110002, China
Di Yang: Corresponding author. Department of Endodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Disease, Nanjing north street 117, Shenyang, 110002, China.; Liaoning Provincial Key Laboratory of Oral Disease, Department of Endodontics, School and Hospital of Stomatology, China Medical University, Shenyang, 110002, China

Journal volume & issue: Vol. 47
pp. 125 – 131

Abstract

Read online

Copper is an essential trace element for the human body. Abnormalities in copper metabolism can lead to bone defects, mainly by directly affecting the viability of osteoblasts and osteoclasts and their bone remodeling function, or indirectly regulating bone metabolism by influencing enzyme activities as cofactors. Copper ions released from biological materials can affect osteoblasts and osteoclasts, either directly or indirectly by modulating the inflammatory response, oxidative stress, and rapamycin signaling. This review presents an overview of recent progress in the impact of copper on bone metabolism.Translational potential of this article: The impact of copper on bone metabolism can provide insights into clinical application of copper-containing supplements and biomaterials.

Published in Journal of Orthopaedic Translation

ISSN: 2214-031X (Print); 2214-0328 (Online)
Publisher: Elsevier
Country of publisher: Hong Kong
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the musculoskeletal system
Website: http://www.journals.elsevier.com/journal-of-orthopaedic-translation/

About the journal

Abstract

Keywords