Hypoglycemic effect of Moringa oleifera leaf extract and its mechanism prediction based on network pharmacology

Zishan Hong; Jing Xie; Huili Hu; Yuying Bai; Xia Hu; Tingting Li; Jinlian Chen; Jun Sheng; Yang Tian

Journal of Future Foods (Dec 2023)

Hypoglycemic effect of Moringa oleifera leaf extract and its mechanism prediction based on network pharmacology

Zishan Hong,
Jing Xie,
Huili Hu,
Yuying Bai,
Xia Hu,
Tingting Li,
Jinlian Chen,
Jun Sheng,
Yang Tian

Affiliations

Zishan Hong: College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China; National Research and Development Professional Center for Moringa Processing Technology, Yunnan Agricultural University, Kunming 650201, China; Yunnan Provincial Engineering Research Center for Edible and Medicinal Homologous Functional Food, Yunnan Agricultural University, Kunming 650201, China
Jing Xie: College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China; National Research and Development Professional Center for Moringa Processing Technology, Yunnan Agricultural University, Kunming 650201, China; Engineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China
Huili Hu: College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China; Engineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China
Yuying Bai: College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China; Yunnan Provincial Engineering Research Center for Edible and Medicinal Homologous Functional Food, Yunnan Agricultural University, Kunming 650201, China
Xia Hu: College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China; National Research and Development Professional Center for Moringa Processing Technology, Yunnan Agricultural University, Kunming 650201, China
Tingting Li: College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China; National Research and Development Professional Center for Moringa Processing Technology, Yunnan Agricultural University, Kunming 650201, China; Engineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China
Jinlian Chen: College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China; Yunnan Provincial Engineering Research Center for Edible and Medicinal Homologous Functional Food, Yunnan Agricultural University, Kunming 650201, China; Engineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China
Jun Sheng: College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China; Corresponding author at: College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Yang Tian: College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China; National Research and Development Professional Center for Moringa Processing Technology, Yunnan Agricultural University, Kunming 650201, China; Yunnan Provincial Engineering Research Center for Edible and Medicinal Homologous Functional Food, Yunnan Agricultural University, Kunming 650201, China; Engineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China; Corresponding author at: College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.

Journal volume & issue: Vol. 3, no. 4
pp. 383 – 391

Abstract

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Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia, which poses a serious threat to human health. Moringa oleifera Lam is a medicinal and edible plant with various physiological functions. However, its main hypoglycemic components and mechanisms are still unclear. In this study, network pharmacology and bioinformatics were used to analyze the potential bioactive substances of M. oleifera leaf extract (MOLE) and its hypoglycemic mechanism. Studies have shown that MOLE has the effect of increasing glucose consumption in insulin resistant-HepG2 cells. MOLE was found to contain 975 compounds by ultrahigh performance liquid chromatography-mass spectrometry (UHPLC-MS). Network pharmacology analysis indicated that the main active component was robinetin and the identified core genes were AKT1 and GAPDH. KEGG pathway enrichment analysis showed that the hypoglycemic effect of MOLE may be closely related to the PI3K-Akt signaling pathway. This study revealed the possible active components and mechanisms of action of M. oleifera for hypoglycemia, laying the theoretical foundation for subsequent studies.

Published in Journal of Future Foods

ISSN: 2772-5669 (Online)
Publisher: KeAi Communications Co. Ltd.
Country of publisher: China
LCC subjects: Technology: Chemical technology: Food processing and manufacture
Website: https://www.keaipublishing.com/en/journals/journal-of-future-foods/

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