Synthesis and diagnosis of a number of new binary zinc complexes with a mixture of lindane (derived from acetyl acetone and semicarbazone) and the study of bio-effectiveness and the effect of laser radiation on them

Abstract

Acetylacetoneazineoxime {AAOH}, acetylacetoneazinebis(oxime) {AABOH2}, benzilsemicarbazone {BScH} and benzilsemicarbazone hydrazone {BScZH} have been prepared using classical, one pot and microwave heating methods followed by the preparation of new zinc(II) complexes in neutral (or slightly acidic) medium with mixed ligands above using classical and microwave heating (Green Chemistry) methods. The resulting complexes have been characterized using elemental analysis by atomic absorption spectroscopy and CHN analysis, relative molecular weight determination cryoscopically, molar conductance measurements, infrared, electronic and 1H NMR spectra. The study suggests that the above ligands form neutral complexes having general formulas [Zn(AH)(BH)(CH3COO)2] (where AH = AAOH or AABOH2; BH=BScH or BScZH ligands). Accordingly, hexa-coordinated mononuclear complexes have been investigated having distorted octahedral geometries. The effect of laser have been studied on solid ligands and solid zinc(II) complexes, no effect have been observed on all the compounds through the results of melting point and conductivity, this means that most of the compounds are stable and not affected by this kind of radiation. Also the activity of all the complexes have been evaluated on Tonsillitis from males and Females. They were found to be unactive against this pathogens.

Keywords

• synthesis
• binary zinc complexes
• mixture of lindane
• acetyl acetone
• semicarbazone