Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses
Casandra Panea,
Adam M. Farkas,
Yoshiyuki Goto,
Shahla Abdollahi-Roodsaz,
Carolyn Lee,
Balázs Koscsó,
Kavitha Gowda,
Tobias M. Hohl,
Milena Bogunovic,
Ivaylo I. Ivanov
Affiliations
Casandra Panea
Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Adam M. Farkas
Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Yoshiyuki Goto
Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Shahla Abdollahi-Roodsaz
Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Carolyn Lee
Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Balázs Koscsó
Department of Microbiology and Immunology, College of Medicine and Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
Kavitha Gowda
Department of Microbiology and Immunology, College of Medicine and Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
Tobias M. Hohl
Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Milena Bogunovic
Department of Microbiology and Immunology, College of Medicine and Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
Ivaylo I. Ivanov
Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Generation of different CD4 T cell responses to commensal and pathogenic bacteria is crucial for maintaining a healthy gut environment, but the associated cellular mechanisms are poorly understood. Dendritic cells (DCs) and macrophages (Mfs) integrate microbial signals and direct adaptive immunity. Although the role of DCs in initiating T cell responses is well appreciated, how Mfs contribute to the generation of CD4 T cell responses to intestinal microbes is unclear. Th17 cells are critical for mucosal immune protection and at steady state are induced by commensal bacteria, such as segmented filamentous bacteria (SFB). Here, we examined the roles of mucosal DCs and Mfs in Th17 induction by SFB in vivo. We show that Mfs, and not conventional CD103+ DCs, are essential for the generation of SFB-specific Th17 responses. Thus, Mfs drive mucosal T cell responses to certain commensal bacteria.
