Neurotrophic factors and their inhibitors in chronic pain treatment

Jayne H. Kelleher; Damini Tewari; Stephen B. McMahon

Neurobiology of Disease (Jan 2017)

Neurotrophic factors and their inhibitors in chronic pain treatment

Jayne H. Kelleher,
Damini Tewari,
Stephen B. McMahon

Affiliations

Jayne H. Kelleher: Corresponding author at: Neurorestoration group, Wolfson Wing, Hodgkin Building, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK.; Neurorestoration group, King's College London, London, UK
Damini Tewari: Neurorestoration group, King's College London, London, UK
Stephen B. McMahon: Neurorestoration group, King's College London, London, UK

Journal volume & issue: Vol. 97
pp. 127 – 138

Abstract

Read online

Chronic pain affects more than 20% of the UK population. Neurotrophic factors have been identified as therapeutic targets to improve current treatments of chronic pain. This review article focuses on nerve growth factor (NGF) and interleukin-6 (IL-6) as potential therapeutic targets. In this review we highlight the mechanisms of action and the current progress of targeted therapies in clinical trials.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

About the journal

Abstract

Keywords