Nature Communications (Sep 2022)
Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia
- Benjamin J. Huang,
- Jenny L. Smith,
- Jason E. Farrar,
- Yi-Cheng Wang,
- Masayuki Umeda,
- Rhonda E. Ries,
- Amanda R. Leonti,
- Erin Crowgey,
- Scott N. Furlan,
- Katherine Tarlock,
- Marcos Armendariz,
- Yanling Liu,
- Timothy I. Shaw,
- Lisa Wei,
- Robert B. Gerbing,
- Todd M. Cooper,
- Alan S. Gamis,
- Richard Aplenc,
- E. Anders Kolb,
- Jeffrey Rubnitz,
- Jing Ma,
- Jeffery M. Klco,
- Xiaotu Ma,
- Todd A. Alonzo,
- Timothy Triche,
- Soheil Meshinchi
Affiliations
- Benjamin J. Huang
- Department of Pediatrics, University of California San Francisco
- Jenny L. Smith
- Fred Hutchinson Cancer Research Center
- Jason E. Farrar
- University of Arkansas for Medical Sciences & Arkansas Children’s Research Institute
- Yi-Cheng Wang
- Children’s Oncology Group
- Masayuki Umeda
- Department of Pathology, St. Jude Children’s Research Hospital
- Rhonda E. Ries
- Fred Hutchinson Cancer Research Center
- Amanda R. Leonti
- Fred Hutchinson Cancer Research Center
- Erin Crowgey
- Nemours Center for Cancer and Blood Disorders and Alfred I. DuPont Hospital for Children
- Scott N. Furlan
- Fred Hutchinson Cancer Research Center
- Katherine Tarlock
- Fred Hutchinson Cancer Research Center
- Marcos Armendariz
- School of Medicine, University of California, San Francisco
- Yanling Liu
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Timothy I. Shaw
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Lisa Wei
- Michael Smith Genome Sciences Centre
- Robert B. Gerbing
- Children’s Oncology Group
- Todd M. Cooper
- Division of Hematology/Oncology, Seattle Children’s Hospital, University of Washington
- Alan S. Gamis
- Children’s Mercy Hospitals and Clinics
- Richard Aplenc
- Children’s Hospital of Philadelphia
- E. Anders Kolb
- Nemours Center for Cancer and Blood Disorders and Alfred I. DuPont Hospital for Children
- Jeffrey Rubnitz
- Department of Oncology, St. Jude Children’s Research Hospital
- Jing Ma
- Department of Pathology, St. Jude Children’s Research Hospital
- Jeffery M. Klco
- Department of Pathology, St. Jude Children’s Research Hospital
- Xiaotu Ma
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Todd A. Alonzo
- Department of Preventive Medicine, University of Southern California
- Timothy Triche
- Van Andel Research Institute
- Soheil Meshinchi
- Fred Hutchinson Cancer Research Center
- DOI
- https://doi.org/10.1038/s41467-022-33244-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Relapsed pediatric acute myeloid leukemia is associated with poor prognosis. Here, the authors use RNA-seq data from 1503 primary samples to create a combined transcriptional and cytomolecular signature to improve relapse risk prediction.
