Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations

Libin Ye; Chris Neale; Adnan Sljoka; Brent Lyda; Dmitry Pichugin; Nobuyuki Tsuchimura; Sacha T. Larda; Régis Pomès; Angel E. García; Oliver P. Ernst; Roger K. Sunahara; R. Scott Prosser

doi:10.1038/s41467-018-03314-9

Nature Communications (Apr 2018)

Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations

Libin Ye,
Chris Neale,
Adnan Sljoka,
Brent Lyda,
Dmitry Pichugin,
Nobuyuki Tsuchimura,
Sacha T. Larda,
Régis Pomès,
Angel E. García,
Oliver P. Ernst,
Roger K. Sunahara,
R. Scott Prosser

Affiliations

Libin Ye: Department of Chemistry, University of Toronto
Chris Neale: Center for Nonlinear Studies, Los Alamos National Laboratory
Adnan Sljoka: Department of Informatics, School of Science and Technology, CREST, Japan Science and Technology Agency (JST), Kwansei Gakuin University
Brent Lyda: Department of Pharmacology, University of California San Diego School of Medicine
Dmitry Pichugin: Department of Chemistry, University of Toronto
Nobuyuki Tsuchimura: Department of Informatics, School of Science and Technology, CREST, Japan Science and Technology Agency (JST), Kwansei Gakuin University
Sacha T. Larda: Department of Chemistry, University of Toronto
Régis Pomès: Department of Biochemistry, University of Toronto
Angel E. García: Center for Nonlinear Studies, Los Alamos National Laboratory
Oliver P. Ernst: Department of Biochemistry, University of Toronto
Roger K. Sunahara: Department of Pharmacology, University of California San Diego School of Medicine
R. Scott Prosser: Department of Chemistry, University of Toronto

DOI: https://doi.org/10.1038/s41467-018-03314-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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G protein-coupled receptors (GPCRs) are membrane receptors and are important drug targets, whose regulation by cations is poorly understood. Here authors use NMR to elucidate effects of cations on functional states of the GPCR, adenosine A2Areceptor (A2AR).

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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