Nature Communications (Feb 2019)

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

  • Shane C. Wright,
  • Paweł Kozielewicz,
  • Maria Kowalski-Jahn,
  • Julian Petersen,
  • Carl-Fredrik Bowin,
  • Greg Slodkowicz,
  • Maria Marti-Solano,
  • David Rodríguez,
  • Belma Hot,
  • Najeah Okashah,
  • Katerina Strakova,
  • Jana Valnohova,
  • M. Madan Babu,
  • Nevin A. Lambert,
  • Jens Carlsson,
  • Gunnar Schulte

DOI
https://doi.org/10.1038/s41467-019-08630-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Class F receptors are therapeutic targets in human disease and understanding their structural changes during receptor activation may provide important pharmacological insight. Here, the authors combine computational and experimental methods to identify a molecular switch in TM6/7 of Class F receptors that mediates receptor activation.