Nature Communications (Aug 2019)

Generation of amine dehydrogenases with increased catalytic performance and substrate scope from ε-deaminating L-Lysine dehydrogenase

  • Vasilis Tseliou,
  • Tanja Knaus,
  • Marcelo F. Masman,
  • Maria L. Corrado,
  • Francesco G. Mutti

DOI
https://doi.org/10.1038/s41467-019-11509-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Amine dehydrogenases (AmDHs) catalyse the conversion of ketones into amines. Here, the authors created AmDH variants, the best of which showing a substrate-dependent stereo-switchable selectivity, affording either S- or R-configured amine products with up to >99.9% enantiomeric excess.