Infection and Drug Resistance (Dec 2021)

In Vitro Activity of Vancomycin, Teicoplanin, Linezolid and Daptomycin Against Methicillin-Resistant Staphylococcus aureus Isolates Collected from Chinese Hospitals in 2018–2020

  • Xu Y,
  • Wang B,
  • Zhao H,
  • Wang X,
  • Rao L,
  • Ai W,
  • Yu J,
  • Guo Y,
  • Wu X,
  • Yu F,
  • Chen S

Journal volume & issue
Vol. Volume 14
pp. 5449 – 5456

Abstract

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Yanlei Xu,1 Bingjie Wang,1 Huilin Zhao,1 Xinyi Wang,1 Lulin Rao,2 Wenxiu Ai,2 Jingyi Yu,1 Yinjuan Guo,1 Xiaocui Wu,1 Fangyou Yu,1 Shuying Chen2 1Department of Clinical Laboratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 2Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaCorrespondence: Fangyou YuDepartment of Clinical Laboratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of ChinaEmail [email protected] ChenDepartment of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaEmail [email protected]: Vancomycin, teicoplanin, linezolid and daptomycin are four major antibacterials used for methicillin-resistant Staphylococcus aureus (MRSA) infection treatment. However, with the increasing failure of clinical MRSA anti-infective treatment, it is urgent to investigate the status of MRSA sensitivity to these four drugs.Methods: In the present study, 407 non-duplicated MRSA isolates from 6 provinces in China were collected from January 2018 to August 2020. The minimum inhibitory concentrations (MICs) of vancomycin, teicoplanin, linezolid and daptomycin were determined by broth microdilution method, and their MIC50, MIC90, and geometric mean MIC were calculated.Results: All 407 MRSA strains were sensitive to these four antibacterials. MIC range of vancomycin, teicoplanin, linezolid and daptomycin was 0.25 to 2 mg/L, 0.125 to 4 mg/L, 0.25 to 4 mg/L and 0.06 to 1 mg/L, respectively. Between 2018 and 2020, there was no “MIC creep” in vancomycin, teicoplanin and daptomycin. The geometric mean MIC of linezolid was not increased, but both MIC50 and MIC90 in 2019 and 2020 MRSA isolates were higher than 2018 isolates.Conclusion: All MRSA isolates remained sensitivity to vancomycin, teicoplanin, linezolid and daptomycin. The linezolid MIC50 and MIC90 increased have been found in this study.Keywords: methicillin-resistant Staphylococcus aureus, vancomycin, teicoplanin, linezolid, daptomycin, MICs

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