Coding and noncoding landscape of extracellular RNA released by human glioma stem cells

Zhiyun Wei; Arsen O. Batagov; Sergio Schinelli; Jintu Wang; Yang Wang; Rachid El Fatimy; Rosalia Rabinovsky; Leonora Balaj; Clark C. Chen; Fred Hochberg; Bob Carter; Xandra O. Breakefield; Anna M. Krichevsky

doi:10.1038/s41467-017-01196-x

Nature Communications (Oct 2017)

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells

Zhiyun Wei,
Arsen O. Batagov,
Sergio Schinelli,
Jintu Wang,
Yang Wang,
Rachid El Fatimy,
Rosalia Rabinovsky,
Leonora Balaj,
Clark C. Chen,
Fred Hochberg,
Bob Carter,
Xandra O. Breakefield,
Anna M. Krichevsky

Affiliations

Zhiyun Wei: Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, HMS Initiative for RNA Medicine
Arsen O. Batagov: Vishuo Biomedical
Sergio Schinelli: Department of Drug Sciences, University of Pavia
Jintu Wang: Beijing Genomics Institute
Yang Wang: Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, HMS Initiative for RNA Medicine
Rachid El Fatimy: Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, HMS Initiative for RNA Medicine
Rosalia Rabinovsky: Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, HMS Initiative for RNA Medicine
Leonora Balaj: Department of Neurology and Radiology, Massachusetts General Hospital and Program in Neuroscience, Harvard Medical School
Clark C. Chen: Neurosurgery Department, University of Minnesota
Fred Hochberg: Department of Neurosurgery, University of California
Bob Carter: Department of Neurosurgery, University of California
Xandra O. Breakefield: Department of Neurology and Radiology, Massachusetts General Hospital and Program in Neuroscience, Harvard Medical School
Anna M. Krichevsky: Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, HMS Initiative for RNA Medicine

DOI: https://doi.org/10.1038/s41467-017-01196-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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While circulating DNA has been extensively explored as a potential cancer biomarker, RNA potential has been overlooked so far. Here the authors present a comprehensive analysis of extracellular RNA secreted by glioblastoma cells that could prove a valuable resource for biomarker discovery and a means of intercellular communication.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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