Communications Biology (Nov 2022)
A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health
- Nora Fernandez-Jimenez,
- Ruby Fore,
- Ariadna Cilleros-Portet,
- Johanna Lepeule,
- Patrice Perron,
- Tuomas Kvist,
- Fu-Ying Tian,
- Corina Lesseur,
- Alexandra M. Binder,
- Manuel Lozano,
- Jordi Martorell-Marugán,
- Yuk J. Loke,
- Kelly M. Bakulski,
- Yihui Zhu,
- Anne Forhan,
- Sara Sammallahti,
- Todd M. Everson,
- Jia Chen,
- Karin B. Michels,
- Thalia Belmonte,
- Pedro Carmona-Sáez,
- Jane Halliday,
- M. Daniele Fallin,
- Janine M. LaSalle,
- Jorg Tost,
- Darina Czamara,
- Mariana F. Fernández,
- Antonio Gómez-Martín,
- Jeffrey M. Craig,
- Beatriz Gonzalez-Alzaga,
- Rebecca J. Schmidt,
- John F. Dou,
- Evelyne Muggli,
- Marina Lacasaña,
- Martine Vrijheid,
- Carmen J. Marsit,
- Margaret R. Karagas,
- Katri Räikkönen,
- Luigi Bouchard,
- Barbara Heude,
- Loreto Santa-Marina,
- Mariona Bustamante,
- Marie-France Hivert,
- Jose Ramon Bilbao
Affiliations
- Nora Fernandez-Jimenez
- Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU) and Biocruces-Bizkaia Health Research Institute
- Ruby Fore
- Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute
- Ariadna Cilleros-Portet
- Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU) and Biocruces-Bizkaia Health Research Institute
- Johanna Lepeule
- University Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB
- Patrice Perron
- Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS)
- Tuomas Kvist
- Department of Psychology and Logopedics, University of Helsinki
- Fu-Ying Tian
- Gangarosa Department of Environmental Health, Rollins School of Public Health at Emory University
- Corina Lesseur
- Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai
- Alexandra M. Binder
- Cancer Epidemiology Program, University of Hawaii Cancer Center
- Manuel Lozano
- Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València
- Jordi Martorell-Marugán
- Department of Statistics and Operations Research, University of Granada
- Yuk J. Loke
- Murdoch Children’s Research Institute
- Kelly M. Bakulski
- Department of Epidemiology, School of Public Health, University of Michigan
- Yihui Zhu
- Department of Medical Microbiology and Immunology, MIND Institute, Genome Center, University of California
- Anne Forhan
- Université de Paris, Centre for Research in Epidemiology and Statistics (CRESS), INSERM, INRAE
- Sara Sammallahti
- Department of Child and Adolescent Psychiatry and Psychology
- Todd M. Everson
- Gangarosa Department of Environmental Health, Rollins School of Public Health at Emory University
- Jia Chen
- Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai
- Karin B. Michels
- Department of Epidemiology, Fielding School of Public Health, University of California
- Thalia Belmonte
- Health Research Institute of Asturias, ISPA and Biomedical Research and Innovation Institute of Cadiz (INiBICA), Research Unit, Puerta del Mar University Hospital
- Pedro Carmona-Sáez
- Department of Statistics and Operations Research, University of Granada
- Jane Halliday
- Murdoch Children’s Research Institute
- M. Daniele Fallin
- Wendy Klag Center for Autism and Developmental Disabilities, Bloomberg School of Public Health, Johns Hopkins University
- Janine M. LaSalle
- Department of Medical Microbiology and Immunology, MIND Institute, Genome Center, University of California
- Jorg Tost
- Laboratory for Epigenetics & Environment, Centre National de Recherche en Génomique Humaine, CEA-Institut de Biologie François Jacob
- Darina Czamara
- Max-Planck-Institute of Psychiatry, Department of Translational Research in Psychiatry
- Mariana F. Fernández
- University of Granada, Center for Biomedical Research (CIBM)
- Antonio Gómez-Martín
- Instituto de Investigación Biosanitaria ibs.GRANADA
- Jeffrey M. Craig
- Murdoch Children’s Research Institute
- Beatriz Gonzalez-Alzaga
- Instituto de Investigación Biosanitaria ibs.GRANADA
- Rebecca J. Schmidt
- Department of Public Health Sciences and the MIND Institute, University of California Davis School of Medicine
- John F. Dou
- Department of Epidemiology, School of Public Health, University of Michigan
- Evelyne Muggli
- Murdoch Children’s Research Institute
- Marina Lacasaña
- Instituto de Investigación Biosanitaria ibs.GRANADA
- Martine Vrijheid
- CIBER of Epidemiology and Public Health (CIBERESP)
- Carmen J. Marsit
- Gangarosa Department of Environmental Health, Rollins School of Public Health at Emory University
- Margaret R. Karagas
- Department of Biochemistry and Functional Genomics, Universite de Sherbrooke
- Katri Räikkönen
- Department of Psychology and Logopedics, University of Helsinki
- Luigi Bouchard
- Department of Biochemistry and Functional Genomics, Universite de Sherbrooke
- Barbara Heude
- Université de Paris, Centre for Research in Epidemiology and Statistics (CRESS), INSERM, INRAE
- Loreto Santa-Marina
- CIBER of Epidemiology and Public Health (CIBERESP)
- Mariona Bustamante
- CIBER of Epidemiology and Public Health (CIBERESP)
- Marie-France Hivert
- Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute
- Jose Ramon Bilbao
- Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU) and Biocruces-Bizkaia Health Research Institute
- DOI
- https://doi.org/10.1038/s42003-022-04267-y
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 11
Abstract
A meta-analysis of pre-pregnancy maternal body mass index (ppBMI) and placental DNA methylation from 2631 mother-child pairs identifies 27 CpG sites associated with ppBMI, providing insight into how maternal obesity could be associated with metabolic health outcomes in offspring.
