Nature Communications (Feb 2022)
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
- Kami Pekayvaz,
- Alexander Leunig,
- Rainer Kaiser,
- Markus Joppich,
- Sophia Brambs,
- Aleksandar Janjic,
- Oliver Popp,
- Daniel Nixdorf,
- Valeria Fumagalli,
- Nora Schmidt,
- Vivien Polewka,
- Afra Anjum,
- Viktoria Knottenberg,
- Luke Eivers,
- Lucas E. Wange,
- Christoph Gold,
- Marieluise Kirchner,
- Maximilian Muenchhoff,
- Johannes C. Hellmuth,
- Clemens Scherer,
- Raquel Rubio-Acero,
- Tabea Eser,
- Flora Deák,
- Kerstin Puchinger,
- Niklas Kuhl,
- Andreas Linder,
- Kathrin Saar,
- Lukas Tomas,
- Christian Schulz,
- Andreas Wieser,
- Wolfgang Enard,
- Inge Kroidl,
- Christof Geldmacher,
- Michael von Bergwelt-Baildon,
- Oliver T. Keppler,
- Mathias Munschauer,
- Matteo Iannacone,
- Ralf Zimmer,
- Philipp Mertins,
- Norbert Hubner,
- Michael Hoelscher,
- Steffen Massberg,
- Konstantin Stark,
- Leo Nicolai
Affiliations
- Kami Pekayvaz
- Department of Medicine I, University Hospital, LMU Munich
- Alexander Leunig
- Department of Medicine I, University Hospital, LMU Munich
- Rainer Kaiser
- Department of Medicine I, University Hospital, LMU Munich
- Markus Joppich
- Department of Informatics, Ludwig-Maximilian Universität München
- Sophia Brambs
- Department of Medicine I, University Hospital, LMU Munich
- Aleksandar Janjic
- Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians University Munich
- Oliver Popp
- Max Delbrück Center for Molecular Medicine (MDC) and Berlin Institute of Health (BIH)
- Daniel Nixdorf
- Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich
- Valeria Fumagalli
- Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute
- Nora Schmidt
- Helmholtz Institute for RNA-based Infection Research, Helmholtz-Center for Infection Research
- Vivien Polewka
- Department of Medicine I, University Hospital, LMU Munich
- Afra Anjum
- Department of Medicine I, University Hospital, LMU Munich
- Viktoria Knottenberg
- Department of Medicine I, University Hospital, LMU Munich
- Luke Eivers
- Department of Medicine I, University Hospital, LMU Munich
- Lucas E. Wange
- Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians University Munich
- Christoph Gold
- Department of Medicine I, University Hospital, LMU Munich
- Marieluise Kirchner
- Max Delbrück Center for Molecular Medicine (MDC) and Berlin Institute of Health (BIH)
- Maximilian Muenchhoff
- Max von Pettenkofer Institute & GeneCenter, Virology, Faculty of Medicine, LMU München
- Johannes C. Hellmuth
- Department of Medicine III, University Hospital, LMU Munich
- Clemens Scherer
- Department of Medicine I, University Hospital, LMU Munich
- Raquel Rubio-Acero
- German Center for Infection Research (DZIF), Partner Site Munich
- Tabea Eser
- German Center for Infection Research (DZIF), Partner Site Munich
- Flora Deák
- German Center for Infection Research (DZIF), Partner Site Munich
- Kerstin Puchinger
- Division of Infectious Diseases and Tropical Medicine, University Hospital Ludwig-Maximilian University Munich
- Niklas Kuhl
- Gene Center and Department of Biochemistry, University Hospital Ludwig-Maximilian University Munich
- Andreas Linder
- Gene Center and Department of Biochemistry, University Hospital Ludwig-Maximilian University Munich
- Kathrin Saar
- Max Delbrück Center for Molecular Medicine (MDC) and Berlin Institute of Health (BIH)
- Lukas Tomas
- Department of Medicine I, University Hospital, LMU Munich
- Christian Schulz
- Department of Medicine I, University Hospital, LMU Munich
- Andreas Wieser
- German Center for Infection Research (DZIF), Partner Site Munich
- Wolfgang Enard
- Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians University Munich
- Inge Kroidl
- German Center for Infection Research (DZIF), Partner Site Munich
- Christof Geldmacher
- German Center for Infection Research (DZIF), Partner Site Munich
- Michael von Bergwelt-Baildon
- Department of Medicine III, University Hospital, LMU Munich
- Oliver T. Keppler
- Max von Pettenkofer Institute & GeneCenter, Virology, Faculty of Medicine, LMU München
- Mathias Munschauer
- Helmholtz Institute for RNA-based Infection Research, Helmholtz-Center for Infection Research
- Matteo Iannacone
- Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute
- Ralf Zimmer
- Department of Informatics, Ludwig-Maximilian Universität München
- Philipp Mertins
- Max Delbrück Center for Molecular Medicine (MDC) and Berlin Institute of Health (BIH)
- Norbert Hubner
- Max Delbrück Center for Molecular Medicine (MDC) and Berlin Institute of Health (BIH)
- Michael Hoelscher
- German Center for Infection Research (DZIF), Partner Site Munich
- Steffen Massberg
- Department of Medicine I, University Hospital, LMU Munich
- Konstantin Stark
- Department of Medicine I, University Hospital, LMU Munich
- Leo Nicolai
- Department of Medicine I, University Hospital, LMU Munich
- DOI
- https://doi.org/10.1038/s41467-022-28508-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
Infection with SARS-COV-2 can result in self-limited upper airway infection or progress to a more systemic inflammatory condition including pneumonic COVID-19. Here the authors utilise a multi-omics approach to interrogate the immune response of patients with self-limiting upper respiratory SARS-CoV-2 infection and reveal a temporal immune trajectory they associate with viral containment and restriction from pneumonic progressive disease.
