An open access resource for functional brain connectivity from fully awake marmosets
David J. Schaeffer,
L Martyn Klassen,
Yuki Hori,
Xiaoguang Tian,
Diego Szczupak,
Cecil Chern-Chyi Yen,
Justine C. Cléry,
Kyle M. Gilbert,
Joseph S. Gati,
Ravi S. Menon,
CiRong Liu,
Stefan Everling,
Afonso C. Silva
Affiliations
David J. Schaeffer
Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, United States; Corresponding author.
L Martyn Klassen
Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada
Yuki Hori
Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada
Xiaoguang Tian
Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, United States
Diego Szczupak
Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, United States
Cecil Chern-Chyi Yen
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States
Justine C. Cléry
Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada
Kyle M. Gilbert
Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada
Joseph S. Gati
Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada
Ravi S. Menon
Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
CiRong Liu
Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
Stefan Everling
Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
Afonso C. Silva
Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, United States
The common marmoset (Callithrix jacchus) is quickly gaining traction as a premier neuroscientific model. However, considerable progress is still needed in understanding the functional and structural organization of the marmoset brain to rival that documented in longstanding preclinical model species, like mice, rats, and Old World primates. To accelerate such progress, we present the Marmoset Functional Brain Connectivity Resource (marmosetbrainconnectome.org), currently consisting of over 70 h of resting-state fMRI (RS-fMRI) data acquired at 500 µm isotropic resolution from 31 fully awake marmosets in a common stereotactic space. Three-dimensional functional connectivity (FC) maps for every cortical and subcortical gray matter voxel are stored online. Users can instantaneously view, manipulate, and download any whole-brain functional connectivity (FC) topology (at the subject- or group-level) along with the raw datasets and preprocessing code. Importantly, researchers can use this resource to test hypotheses about FC directly – with no additional analyses required – yielding whole-brain correlations for any gray matter voxel on demand. We demonstrate the resource's utility for presurgical planning and comparison with tracer-based neuronal connectivity as proof of concept. Complementing existing structural connectivity resources for the marmoset brain, the Marmoset Functional Brain Connectivity Resource affords users the distinct advantage of exploring the connectivity of any voxel in the marmoset brain, not limited to injection sites nor constrained by regional atlases. With the entire raw database (RS-fMRI and structural images) and preprocessing code openly available for download and use, we expect this resource to be broadly valuable to test novel hypotheses about the functional organization of the marmoset brain.
