Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure

• Wolfgang Dohle,
• Andrea E. Prota,
• Grégory Menchon,
• Ernest Hamel,
• Michel O. Steinmetz,
• Barry V. L. Potter

Affiliations

Wolfgang Dohle

Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Oxford, U.K.

Andrea E. Prota

Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, Villigen PSI, Switzerland

Grégory Menchon

Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, Villigen PSI, Switzerland

Ernest Hamel

Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States

Michel O. Steinmetz

Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, Villigen PSI, Switzerland

Barry V. L. Potter

Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Oxford, U.K.