Nature Communications (Jan 2018)
The protective role of DOT1L in UV-induced melanomagenesis
- Bo Zhu,
- Shuyang Chen,
- Hongshen Wang,
- Chengqian Yin,
- Changpeng Han,
- Cong Peng,
- Zhaoqian Liu,
- Lixin Wan,
- Xiaoyang Zhang,
- Jie Zhang,
- Christine G. Lian,
- Peilin Ma,
- Zhi-xiang Xu,
- Sharon Prince,
- Tao Wang,
- Xiumei Gao,
- Yujiang Shi,
- Dali Liu,
- Min Liu,
- Wenyi Wei,
- Zhi Wei,
- Jingxuan Pan,
- Yongjun Wang,
- Zhenyu Xuan,
- Jay Hess,
- Nicholas K. Hayward,
- Colin R. Goding,
- Xiang Chen,
- Jun Zhou,
- Rutao Cui
Affiliations
- Bo Zhu
- Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine
- Shuyang Chen
- Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine
- Hongshen Wang
- Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine
- Chengqian Yin
- Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine
- Changpeng Han
- Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine
- Cong Peng
- Department of Dermatology & China Hunan key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University
- Zhaoqian Liu
- Department of Dermatology & China Hunan key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University
- Lixin Wan
- Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Xiaoyang Zhang
- Dana-Farber Cancer Institute
- Jie Zhang
- Department of Computer Science, New Jersey Institute of Technology
- Christine G. Lian
- Department of Pathology, The Brigham and Women’s Hospital, Harvard Medical School
- Peilin Ma
- Department of Pathology, Indiana University School of Medicine
- Zhi-xiang Xu
- Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham School of Medicine
- Sharon Prince
- Department of Human Biology, University of Cape Town
- Tao Wang
- Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine
- Xiumei Gao
- Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine
- Yujiang Shi
- Department of Medicine, Endocrinology, Brigham and Women’s Hospital, Harvard Medical School
- Dali Liu
- Department of Chemistry and Biochemistry, Loyola University Chicago
- Min Liu
- Shandong Provincial Key Laboratory of Animal Resistance Biology, Institute of Biomedical Sciences, College of Life Sciences, Shandong Normal University
- Wenyi Wei
- Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Zhi Wei
- Department of Computer Science, New Jersey Institute of Technology
- Jingxuan Pan
- Cancer Pharmacology Research Institute, Jinan University
- Yongjun Wang
- Shanghai University of Traditional Chinese Medicine
- Zhenyu Xuan
- Department of Biological Sciences, Center for Systems Biology, University of Texas at Dallas
- Jay Hess
- Department of Pathology, Indiana University School of Medicine
- Nicholas K. Hayward
- QIMR Berghofer Medical Research Institute
- Colin R. Goding
- Ludwig Institute for Cancer Research, University of Oxford
- Xiang Chen
- Department of Dermatology & China Hunan key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University
- Jun Zhou
- Shandong Provincial Key Laboratory of Animal Resistance Biology, Institute of Biomedical Sciences, College of Life Sciences, Shandong Normal University
- Rutao Cui
- Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-017-02687-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
The interaction of DOT1L with MLL oncogenic fusion proteins has been implicated in leukemogenesis. Here, the authors show a contrasting role for DOT1L in protecting UVR-induced melanomagenesis by facilitating DNA repair through interaction with XPC.
