Frontiers in Public Health (Feb 2022)
Development and Validation of a Competitive Risk Model in Elderly Patients With Chromophobe Cell Renal Carcinoma: A Population-Based Study
- Jinkui Wang,
- Jinkui Wang,
- Jinkui Wang,
- Jinkui Wang,
- Jinkui Wang,
- Jinkui Wang,
- Jinkui Wang,
- Chenghao Zhanghuang,
- Chenghao Zhanghuang,
- Chenghao Zhanghuang,
- Chenghao Zhanghuang,
- Chenghao Zhanghuang,
- Chenghao Zhanghuang,
- Chenghao Zhanghuang,
- Chenghao Zhanghuang,
- Chenghao Zhanghuang,
- Xiaojun Tan,
- Xiaojun Tan,
- Xiaojun Tan,
- Xiaojun Tan,
- Xiaojun Tan,
- Xiaojun Tan,
- Xiaojun Tan,
- Tao Mi,
- Tao Mi,
- Tao Mi,
- Tao Mi,
- Tao Mi,
- Tao Mi,
- Tao Mi,
- Jiayan Liu,
- Jiayan Liu,
- Jiayan Liu,
- Jiayan Liu,
- Jiayan Liu,
- Jiayan Liu,
- Jiayan Liu,
- Liming Jin,
- Liming Jin,
- Liming Jin,
- Liming Jin,
- Liming Jin,
- Liming Jin,
- Liming Jin,
- Mujie Li,
- Mujie Li,
- Mujie Li,
- Mujie Li,
- Mujie Li,
- Mujie Li,
- Mujie Li,
- Zhaoxia Zhang,
- Zhaoxia Zhang,
- Zhaoxia Zhang,
- Zhaoxia Zhang,
- Zhaoxia Zhang,
- Zhaoxia Zhang,
- Zhaoxia Zhang,
- Dawei He,
- Dawei He,
- Dawei He,
- Dawei He,
- Dawei He,
- Dawei He,
- Dawei He
Affiliations
- Jinkui Wang
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Jinkui Wang
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Jinkui Wang
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Jinkui Wang
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Jinkui Wang
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Jinkui Wang
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Jinkui Wang
- Children's Hospital of Chongqing Medical University, Chongqing, China
- Chenghao Zhanghuang
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Chenghao Zhanghuang
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Chenghao Zhanghuang
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Chenghao Zhanghuang
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Chenghao Zhanghuang
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Chenghao Zhanghuang
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Chenghao Zhanghuang
- Children's Hospital of Chongqing Medical University, Chongqing, China
- Chenghao Zhanghuang
- Department of Urology, Kunming Children's Hospital, Kunming, China
- Chenghao Zhanghuang
- Yunnan Provincial Key Research Laboratory of Pediatric Major Diseases, Kunming, China
- Xiaojun Tan
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Xiaojun Tan
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Xiaojun Tan
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Xiaojun Tan
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Xiaojun Tan
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Xiaojun Tan
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Xiaojun Tan
- Children's Hospital of Chongqing Medical University, Chongqing, China
- Tao Mi
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Tao Mi
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Tao Mi
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Tao Mi
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Tao Mi
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Tao Mi
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Tao Mi
- Children's Hospital of Chongqing Medical University, Chongqing, China
- Jiayan Liu
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Jiayan Liu
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Jiayan Liu
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Jiayan Liu
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Jiayan Liu
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Jiayan Liu
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Jiayan Liu
- Children's Hospital of Chongqing Medical University, Chongqing, China
- Liming Jin
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Liming Jin
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Liming Jin
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Liming Jin
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Liming Jin
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Liming Jin
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Liming Jin
- Children's Hospital of Chongqing Medical University, Chongqing, China
- Mujie Li
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Mujie Li
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Mujie Li
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Mujie Li
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Mujie Li
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Mujie Li
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Mujie Li
- Children's Hospital of Chongqing Medical University, Chongqing, China
- Zhaoxia Zhang
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Zhaoxia Zhang
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Zhaoxia Zhang
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Zhaoxia Zhang
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Zhaoxia Zhang
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Zhaoxia Zhang
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Zhaoxia Zhang
- Children's Hospital of Chongqing Medical University, Chongqing, China
- Dawei He
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Dawei He
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Dawei He
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Dawei He
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Dawei He
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Dawei He
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Dawei He
- Children's Hospital of Chongqing Medical University, Chongqing, China
- DOI
- https://doi.org/10.3389/fpubh.2022.840525
- Journal volume & issue
-
Vol. 10
Abstract
BackgroundRenal cell carcinoma (RCC) is the most common renal malignancy in adults, and chromophobe renal cell carcinoma (chRCC) is the third most common subtype of RCC. We aimed to construct a competitive risk model to predict cancer-specific survival (CSS) in elderly patients with chRCC.MethodsThe clinicopathological information of the patients was downloaded from the SEER database, and the patients were randomly divided into the training and validation cohorts. Patients' risk factors for cancer-specific death (CSM) were analyzed using proportional subdistribution hazard (SH). We constructed a competitive risk model to predict the CSS of elderly chRCC patients. Consistency index (C-index), the area under receiver operating curve (AUC), and a calibration curve were used to validate the model's accuracy. Decision curve analysis (DCA) was used to test the clinical value of the model.ResultsA total of 3,522 elderly patients with chRCC were included in the analysis. Patients were randomly assigned to either the training cohort (N = 2,474) or the validation cohort (N = 1,048). SH analysis found that age, race, T, N, and M stage, tumor size, and surgery were risk factors for CSM. We constructed a competitive risk model to predict patients' CSS. In the training set, the model predicted patients' 1-, 3-, and 5-year CSS with C-indices of 82.2, 80.8, and 78.2, respectively. The model predicted patient 1-, 3-, and 5-year CSS in the validation cohort with C-indices of 84.7, 83.4, and 76.9, respectively. The calibration curve showed that the model's predicted value is almost consistent with the observed value, which indicated that the model has good accuracy. The AUC of the training set and validation queue also suggested that the model has good discrimination. The clinical utility of the DCA model in predicting patients' CSS is higher than that of traditional TNM staging.ConclusionsWe constructed a competitive risk model to predict CSS in elderly patients with chRCC. The model has good accuracy and reliability, which can help doctors and patients to make clinical decisions and follow-up strategies.
Keywords
