A kinetically controlled platform for ligand-oligonucleotide transduction

Qiu-Long Zhang; Liang-Liang Wang; Yan Liu; Jiao Lin; Liang Xu

doi:10.1038/s41467-021-24962-4

Nature Communications (Aug 2021)

A kinetically controlled platform for ligand-oligonucleotide transduction

Qiu-Long Zhang,
Liang-Liang Wang,
Yan Liu,
Jiao Lin,
Liang Xu

Affiliations

Qiu-Long Zhang: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University
Liang-Liang Wang: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University
Yan Liu: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University
Jiao Lin: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University
Liang Xu: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University

DOI: https://doi.org/10.1038/s41467-021-24962-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

Ligand-oligonucleotide interactions can integrate both small molecules and proteins into nucleic acid-based circuits. Here the authors design ligand-aptamer complexes to control strand-displacement reactions for versatile ligand transduction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal