EXPERIMENTAL AND CLINICAL EPILEPTOLOGY

G. N. Avakyan; O. L. Badalyan; S. G. Burd; Е. А. Valdman; Т. А. Voronina; L. N. Nerobkova; Е. V. Krikova; G. G. Аvakyan; A. S. Chukanova; M. I. Stoyko; А. А. Savenkov

Эпилепсия и пароксизмальные состояния (Aug 2016)

EXPERIMENTAL AND CLINICAL EPILEPTOLOGY

G. N. Avakyan,
O. L. Badalyan,
S. G. Burd,
Е. А. Valdman,
Т. А. Voronina,
L. N. Nerobkova,
Е. V. Krikova,
G. G. Аvakyan,
A. S. Chukanova,
M. I. Stoyko,
А. А. Savenkov

Affiliations

G. N. Avakyan: GOU VPO “Russian state medical university named after N.I. Pirogov” of Roszdrav
O. L. Badalyan: GOU VPO “Russian state medical university named after N.I. Pirogov” of Roszdrav
S. G. Burd: GOU VPO “Russian state medical university named after N.I. Pirogov” of Roszdrav
Е. А. Valdman: GU scientific research institute of pharmacology named after V.V. Zakusov of RAMS
Т. А. Voronina: GU scientific research institute of pharmacology named after V.V. Zakusov of RAMS
L. N. Nerobkova: GU scientific research institute of pharmacology named after V.V. Zakusov of RAMS
Е. V. Krikova: GU scientific research institute of pharmacology named after V.V. Zakusov of RAMS
G. G. Аvakyan: GOU VPO “Russian state medical university named after N.I. Pirogov” of Roszdrav
A. S. Chukanova: GOU VPO “Russian state medical university named after N.I. Pirogov” of Roszdrav
M. I. Stoyko: GOU VPO “Russian state medical university named after N.I. Pirogov” of Roszdrav
А. А. Savenkov: GOU VPO “Russian state medical university named after N.I. Pirogov” of Roszdrav

Journal volume & issue: Vol. 2, no. 4
pp. 41 – 54

Abstract

Read online

This article reviews the issues of experimental and clinical epileptology. For the development and implementation of new medications and technologies of medicinal interventions, as well as investigation of main “targets” for anti-epileptic drugs, it is necessary to develop the experimental models of various forms of epilepsy and epileptic seizures. To this end, we studied the alterations of cerebral electrical activity in rats with chronic cobalt epileptogenic focus which represents an optimal experimental model of epileptic state. The significance of hypothalamus was shown to be the lead (determinate) structure within the pathologic epileptic system during formation of secondary generalized seizures. The drug” targets” and possibilities for combined administration of anticonvulsants and antioxidants have been revealed. Pharmaco-genetic investigations enable us to predict the effects of different antiepileptic drugs.

Published in Эпилепсия и пароксизмальные состояния

ISSN: 2077-8333 (Print); 2311-4088 (Online)
Publisher: IRBIS LLC
Country of publisher: Russian Federation
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.epilepsia.su

About the journal

Abstract

Keywords