Dermatopathology (Nov 2014)

Perineural Invasion in the Absence of Malignancy: Report of Two Cases and Review of the Literature

  • Katrin Pfaltz,
  • André Barghorn,
  • Werner Kempf

DOI
https://doi.org/10.1159/000368600
Journal volume & issue
Vol. 1, no. 2
pp. 86 – 90

Abstract

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Perineural invasion is usually associated with invasion of the perineural space by malignant tumors. In this report, we describe 2 cases of perineural infiltration by benign-appearing epithelial cells in the skin. One case concerns a tumor-free reexcision specimen of a basal cell carcinoma and the other one an ulceration at the outer ear, consistent with acanthoma fissuratum, without a history of a previous excision. This finding was interpreted as a reactive process with dislocation of epithelium from the overlying epidermis into the perineural space. © 2014 S. Karger AG, Basel

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