Modern Medicine (Jun 2021)

Is the Importance of Magnesium in Chronic Kidney Disease Underappreciated?

  • Delia TIMOFTE,
  • Andra-Elena BALCANGIU-STROESCU,
  • Dorin DRAGOS,
  • Maria Daniela TANASESCU,
  • Iuliana GHENU,
  • Ileana Adela VACAROIU,
  • Adrian TULIN,
  • Adina MANDITA,
  • Ovidiu STIRU,
  • Doina Andrada MIHAI,
  • Anca Macovei OPRESCU,
  • Iulian SLAVU,
  • Dorin IONESCU,
  • Cornelia NITIPIR

DOI
https://doi.org/10.31689/rmm.2021.28.2.139
Journal volume & issue
Vol. 28, no. 2
pp. 139 – 144

Abstract

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Magnesium (Mg) is one of the most important cations in the organism, essential for regulating vascular tone, cardiac rhythm, and endothelial functions. In patients with advanced stage chronic kidney disease (CKD) Mg deficit was associated in various studies with vascular calcifications and increased cardiovascular morbidity and mortality. Patients with CKD frequently have hyperparathyroidism, parathormone (PTH) being an important risk factor for vascular calcifications. Increased serum Mg levels inhibit PTH secretion and stimulate left ventricular hypertrophy, while low serum Mg levels stimulate PTH secretion. Correcting Mg de deficiency results in reduced cardiovascular mortality in these patients.

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