Nature Communications (Nov 2021)

Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5

  • Eunyoung Jeong,
  • Yoojoong Kim,
  • Jihong Jeong,
  • Yunje Cho

DOI
https://doi.org/10.1038/s41467-021-27147-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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The orphan GPR158 receptor belongs to the class C GPCR family and interacts with the regulator of G protein signaling 7 (RGS7)-Gβ5 complex. Here, the authors present the cryo-EM structure of human GPR158, which reveals that the extracellular domain contains a PAS domain, and they also determine the structures of GPR158 in complex with either one or two RGS7-Gβ5 heterodimers and discuss implications for the signaling mechanism.