Structures of non-cellular tissues of the body and their importance in otorhinolaryngology

Abstract

We present the results of our studies in various pathological conditions in otorhinolaryngology performed with a diagnostic technology of functional morphology of non-cellular tissue structures (mouth fluid, surgical wound exudation, blood serum, and others). With the use of methods of cuniform and marginal dehydration of biological fluids, the possibility of developing essentially novel criteria was shown, such as:• prediction of complicated course of post-operative wound healing in subjects with a lamellar morphotype in the wound exudation resulting from cholesterol residues due to massive cell death;• prediction of a polypous rhinosinusitis relapse in subjects with an increase in the proliferation marker, anisotropic parallels lines in the dehydrated serum obtained from the blood taken from the inferior nasal turbinate;• diagnostics of the middle ear cholesteatoma in children by combination of cuniform and marginal dehydration of the mouth fluid. The singularity of the technique is based on triple sampling of the fluid: first sample was taken immediately after awakening, the second one, after a few minutes of active swallowing movements and the third one, after trans-tympanicair pumping. Detection of the structural signs of congestive effusion and the lamellar morphotype as a destruction marker in the third sample suggested the presence of cholesteatoma;• assessment of treatment efficacy in patients with chronic tonsillitis and of the indications to tonsillectomy in patients with persisting pathological characteristics of the exudation from the palatal tonsil lacunes throughout the whole course of conservative treatment;• determination of the grade of activity / absence of activity of laryngeal cancer by identification of a basic spherolith with various degrees of anisotropy, abnormally aggregated with a granular microspherolith;• detection of the signs of progression in laryngeal cancer by the presence of wave-shaped structures in the microspherolith during radiation therapy.

Keywords

• diagnosis
• biological fluids
• structure of non-cellular tissues
• cholesteatoma of the middle ear
• polypous rhinosinusitis
• chronic tonsilli tis
• larynx cancer