IMPACT OF CYTOKINES UPON COMORBID STATES OF CORONARY ARTERY DISEASE AND AFFECTIVE DISORDERS ASSOCIATED WITH DEPRESSION AND ANXIETY

Abstract

The aim of present work was to study IL-1β, IL-6, and TNFα levels in the patients with coronary artery disease (CAD) accompanied by anxiety and depression. We have revealed a significant increase in IL-6 and TNFα in the patients with ischemic CAD associated with comorbid affective disturbances, as compared to the persons with CAD free of mood disorders. Our results support a «cytokine» hypothesis of affective disturbances in CAD patients, i.e., in cases associated with anxiety and depression.

Keywords

• coronary artery disease
• depression
• anxiety
• cytokines