Nature Communications (Jun 2021)

Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay

  • Aijie Cai,
  • Wenhao Yan,
  • Xiaojun Zeng,
  • Samson B. Zacate,
  • Tzu-Hsuan Chao,
  • Jeanette A. Krause,
  • Mu-Jeng Cheng,
  • Wei Liu

DOI
https://doi.org/10.1038/s41467-021-23590-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Compounds that contain alkyl-difluoromethyl moieties are of interest for medicinal chemistry, but their synthesis is challenging. Here, the authors report a copper-catalyzed radical relay approach for the carbodifluoromethylation of alkenes that simultaneously introduces CF2H groups and complex alkyl or aryl groups into alkenes.