A case of precipitate in intravenous line when general anesthesia implemented with remimazolam
Yingge Liu,
Minhui Liao,
Xiaoqiao Sang,
Zhou Zhou,
Xiaobao Zhang
Affiliations
Yingge Liu
Department of Anesthesiology, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China
Minhui Liao
Department of Anesthesiology, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China
Xiaoqiao Sang
Department of Anesthesiology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, China
Zhou Zhou
Department of Anesthesiology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, China
Xiaobao Zhang
Department of Anesthesiology, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China; Department of Anesthesiology, Kangda College of Nanjing Medical University, Lianyungang, China; Corresponding author.
Adverse reactions caused by drug compatibility are more common in clinical practice, including discoloration, precipitation, crystallization, which can be life-threatening in severe cases. We report a 63-year-old man who developed precipitation during maintenance of general anesthesia with remimazolam tosylate for prostate resection. There were many precipitates in the infusion pipeline and the three-way stopcock, and at that time the infusion liquid was Ringer's acetate solution. Then we investigated the possibility of precipitation with different infusion fluids and remimazolam tosylate. In conclusion, precipitates may not form at a lower remimazolam tosylate concentration and a faster liquid infusion rate and require appropriate attention.
