An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells

Xiaofeng Huang; Min Zheng; Pui Wang; Bobo Wing-Yee Mok; Siwen Liu; Siu-Ying Lau; Pin Chen; Yen-Chin Liu; Honglian Liu; Yixin Chen; Wenjun Song; Kwok-Yung Yuen; Honglin Chen

doi:10.1038/ncomms14751

Nature Communications (Mar 2017)

An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells

Xiaofeng Huang,
Min Zheng,
Pui Wang,
Bobo Wing-Yee Mok,
Siwen Liu,
Siu-Ying Lau,
Pin Chen,
Yen-Chin Liu,
Honglian Liu,
Yixin Chen,
Wenjun Song,
Kwok-Yung Yuen,
Honglin Chen

Affiliations

Xiaofeng Huang: Department of Microbiology, State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong
Min Zheng: Department of Microbiology, State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong
Pui Wang: Department of Microbiology, State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong
Bobo Wing-Yee Mok: Department of Microbiology, State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong
Siwen Liu: Department of Microbiology, State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong
Siu-Ying Lau: Department of Microbiology, State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong
Pin Chen: Department of Microbiology, State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong
Yen-Chin Liu: Department of Microbiology, State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong
Honglian Liu: Department of Microbiology, State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong
Yixin Chen: National Institute of Diagnostics and Vaccine Development in Infectious Diseases, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University
Wenjun Song: Department of Microbiology, State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong
Kwok-Yung Yuen: Department of Microbiology, State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong
Honglin Chen: Department of Microbiology, State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong

DOI: https://doi.org/10.1038/ncomms14751
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Some circulating avian influenza A viruses can infect humans, but the mechanism enabling species jump is poorly understood. Here, Huanget al. identify a nucleotide in NEP of avian H7N9 viruses that affects splicing efficiency of the NS segment and supports virus replication in avian and mammalian cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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