Nature Communications (Dec 2021)
Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis
- Yoshihiro Matsumura,
- Ryo Ito,
- Ayumu Yajima,
- Rei Yamaguchi,
- Toshiya Tanaka,
- Takeshi Kawamura,
- Kenta Magoori,
- Yohei Abe,
- Aoi Uchida,
- Takeshi Yoneshiro,
- Hiroyuki Hirakawa,
- Ji Zhang,
- Makoto Arai,
- Chaoran Yang,
- Ge Yang,
- Hiroki Takahashi,
- Hitomi Fujihashi,
- Ryo Nakaki,
- Shogo Yamamoto,
- Satoshi Ota,
- Shuichi Tsutsumi,
- Shin-ichi Inoue,
- Hiroshi Kimura,
- Youichiro Wada,
- Tatsuhiko Kodama,
- Takeshi Inagaki,
- Timothy F. Osborne,
- Hiroyuki Aburatani,
- Koichi Node,
- Juro Sakai
Affiliations
- Yoshihiro Matsumura
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Ryo Ito
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Ayumu Yajima
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Rei Yamaguchi
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Toshiya Tanaka
- Department of Nuclear Receptor Medicine, Laboratories for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Takeshi Kawamura
- Isotope Science Center, The University of Tokyo
- Kenta Magoori
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Yohei Abe
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Aoi Uchida
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Takeshi Yoneshiro
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Hiroyuki Hirakawa
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Ji Zhang
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Makoto Arai
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Chaoran Yang
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Ge Yang
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Hiroki Takahashi
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Hitomi Fujihashi
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Ryo Nakaki
- Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo
- Shogo Yamamoto
- Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo
- Satoshi Ota
- Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo
- Shuichi Tsutsumi
- Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo
- Shin-ichi Inoue
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Hiroshi Kimura
- Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology
- Youichiro Wada
- Isotope Science Center, The University of Tokyo
- Tatsuhiko Kodama
- Department of Nuclear Receptor Medicine, Laboratories for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Takeshi Inagaki
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Timothy F. Osborne
- Institute for Fundamental Biomedical Research, Johns Hopkins All Children’s Hospital, and Medicine in the Division of Endocrinology, Diabetes and Metabolism of the Johns Hopkins University School of Medicine
- Hiroyuki Aburatani
- Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo
- Koichi Node
- Department of Cardiovascular Medicine, Saga University
- Juro Sakai
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-021-27321-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
How enhancers transition from a hypoacetylated primed state to a hyperacetylated-active state in response to differentiation stimuli is incompletely understood. Here the authors show that SETD5 forms a complex with NCoR-HDAC3 co-repressor to prevent histone acetylation of master adipogenic gene enhancers, while SETD5 degradation triggers enhancer hyperacetylation and transition to active state.
