Streptococcus suis surface-antigen recognition by antibodies and bacterial elimination is influenced by capsular polysaccharide structure

Dominic Dolbec; Mélanie Lehoux; Masatoshi Okura; Daisuke Takamatsu; Daisuke Takamatsu; Daisuke Takamatsu; Marcelo Gottschalk; Mariela Segura

doi:10.3389/fcimb.2023.1228496

Frontiers in Cellular and Infection Microbiology (Jul 2023)

Streptococcus suis surface-antigen recognition by antibodies and bacterial elimination is influenced by capsular polysaccharide structure

Dominic Dolbec,
Mélanie Lehoux,
Masatoshi Okura,
Daisuke Takamatsu,
Daisuke Takamatsu,
Daisuke Takamatsu,
Marcelo Gottschalk,
Mariela Segura

Affiliations

Dominic Dolbec: Research Group on Infectious Diseases in Production Animals (GREMIP) and Swine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada
Mélanie Lehoux: Research Group on Infectious Diseases in Production Animals (GREMIP) and Swine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada
Masatoshi Okura: Division of Transboundary Animal Disease Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Kagoshima, Japan
Daisuke Takamatsu: Division of Infectious Animal Disease Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Japan
Daisuke Takamatsu: The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan
Daisuke Takamatsu: Joint Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan
Marcelo Gottschalk: Research Group on Infectious Diseases in Production Animals (GREMIP) and Swine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada
Mariela Segura: Research Group on Infectious Diseases in Production Animals (GREMIP) and Swine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada

DOI: https://doi.org/10.3389/fcimb.2023.1228496
Journal volume & issue: Vol. 13

Abstract

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Streptococcus suis is an encapsulated bacterium causing severe diseases in swine. Here, we compared the protective properties of the capsular polysaccharide (CPS) of different S. suis serotypes by using serotype-switched mutants in a mouse model of infection. CPS structure influenced bacterial survival in mice, antibody binding, and antibody-mediated bacterial killing. The CPS of serotypes 3, 4 and 14 allowed more antibody binding and bacterial elimination than the CPS of serotypes 2, 7 and 9. Results suggest that the different CPS structures of S. suis provide varying levels of protection by influencing antigen availability and elimination by the host immune system.

Published in Frontiers in Cellular and Infection Microbiology

ISSN: 2235-2988 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/Cellular-and-Infection-Microbiology

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