Frontiers in Nutrition (Mar 2023)
Mechanism of skeletal muscle atrophy after spinal cord injury: A narrative review
- Xin Xu,
- Xin Xu,
- Xin Xu,
- Xin Xu,
- Xin Xu,
- Zuliyaer Talifu,
- Zuliyaer Talifu,
- Zuliyaer Talifu,
- Zuliyaer Talifu,
- Zuliyaer Talifu,
- Zuliyaer Talifu,
- Chun-Jia Zhang,
- Chun-Jia Zhang,
- Chun-Jia Zhang,
- Chun-Jia Zhang,
- Chun-Jia Zhang,
- Feng Gao,
- Feng Gao,
- Feng Gao,
- Feng Gao,
- Feng Gao,
- Han Ke,
- Han Ke,
- Han Ke,
- Han Ke,
- Han Ke,
- Han Ke,
- Yun-Zhu Pan,
- Yun-Zhu Pan,
- Yun-Zhu Pan,
- Yun-Zhu Pan,
- Yun-Zhu Pan,
- Yun-Zhu Pan,
- Han Gong,
- Han Gong,
- Han Gong,
- Han Gong,
- Han Gong,
- Hua-Yong Du,
- Hua-Yong Du,
- Hua-Yong Du,
- Hua-Yong Du,
- Hua-Yong Du,
- Yan Yu,
- Yan Yu,
- Yan Yu,
- Yan Yu,
- Ying-Li Jing,
- Ying-Li Jing,
- Ying-Li Jing,
- Ying-Li Jing,
- Liang-Jie Du,
- Liang-Jie Du,
- Liang-Jie Du,
- Liang-Jie Du,
- Liang-Jie Du,
- Jian-Jun Li,
- Jian-Jun Li,
- Jian-Jun Li,
- Jian-Jun Li,
- Jian-Jun Li,
- Jian-Jun Li,
- De-Gang Yang,
- De-Gang Yang,
- De-Gang Yang,
- De-Gang Yang,
- De-Gang Yang
Affiliations
- Xin Xu
- School of Rehabilitation, Capital Medical University, Beijing, China
- Xin Xu
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Xin Xu
- Chinese Institute of Rehabilitation Science, Beijing, China
- Xin Xu
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Xin Xu
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Zuliyaer Talifu
- School of Rehabilitation, Capital Medical University, Beijing, China
- Zuliyaer Talifu
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Zuliyaer Talifu
- Chinese Institute of Rehabilitation Science, Beijing, China
- Zuliyaer Talifu
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Zuliyaer Talifu
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Zuliyaer Talifu
- School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, Shandong, China
- Chun-Jia Zhang
- School of Rehabilitation, Capital Medical University, Beijing, China
- Chun-Jia Zhang
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Chun-Jia Zhang
- Chinese Institute of Rehabilitation Science, Beijing, China
- Chun-Jia Zhang
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Chun-Jia Zhang
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Feng Gao
- School of Rehabilitation, Capital Medical University, Beijing, China
- Feng Gao
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Feng Gao
- Chinese Institute of Rehabilitation Science, Beijing, China
- Feng Gao
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Feng Gao
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Han Ke
- School of Rehabilitation, Capital Medical University, Beijing, China
- Han Ke
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Han Ke
- Chinese Institute of Rehabilitation Science, Beijing, China
- Han Ke
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Han Ke
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Han Ke
- School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, Shandong, China
- Yun-Zhu Pan
- School of Rehabilitation, Capital Medical University, Beijing, China
- Yun-Zhu Pan
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Yun-Zhu Pan
- Chinese Institute of Rehabilitation Science, Beijing, China
- Yun-Zhu Pan
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Yun-Zhu Pan
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Yun-Zhu Pan
- School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, Shandong, China
- Han Gong
- School of Rehabilitation, Capital Medical University, Beijing, China
- Han Gong
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Han Gong
- Chinese Institute of Rehabilitation Science, Beijing, China
- Han Gong
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Han Gong
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Hua-Yong Du
- School of Rehabilitation, Capital Medical University, Beijing, China
- Hua-Yong Du
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Hua-Yong Du
- Chinese Institute of Rehabilitation Science, Beijing, China
- Hua-Yong Du
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Hua-Yong Du
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Yan Yu
- School of Rehabilitation, Capital Medical University, Beijing, China
- Yan Yu
- Chinese Institute of Rehabilitation Science, Beijing, China
- Yan Yu
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Yan Yu
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Ying-Li Jing
- School of Rehabilitation, Capital Medical University, Beijing, China
- Ying-Li Jing
- Chinese Institute of Rehabilitation Science, Beijing, China
- Ying-Li Jing
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Ying-Li Jing
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Liang-Jie Du
- School of Rehabilitation, Capital Medical University, Beijing, China
- Liang-Jie Du
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Liang-Jie Du
- Chinese Institute of Rehabilitation Science, Beijing, China
- Liang-Jie Du
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Liang-Jie Du
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Jian-Jun Li
- School of Rehabilitation, Capital Medical University, Beijing, China
- Jian-Jun Li
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Jian-Jun Li
- Chinese Institute of Rehabilitation Science, Beijing, China
- Jian-Jun Li
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Jian-Jun Li
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Jian-Jun Li
- School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, Shandong, China
- De-Gang Yang
- School of Rehabilitation, Capital Medical University, Beijing, China
- De-Gang Yang
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- De-Gang Yang
- Chinese Institute of Rehabilitation Science, Beijing, China
- De-Gang Yang
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- De-Gang Yang
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- DOI
- https://doi.org/10.3389/fnut.2023.1099143
- Journal volume & issue
-
Vol. 10
Abstract
Spinal cord injury leads to loss of innervation of skeletal muscle, decreased motor function, and significantly reduced load on skeletal muscle, resulting in atrophy. Factors such as braking, hormone level fluctuation, inflammation, and oxidative stress damage accelerate skeletal muscle atrophy. The atrophy process can result in skeletal muscle cell apoptosis, protein degradation, fat deposition, and other pathophysiological changes. Skeletal muscle atrophy not only hinders the recovery of motor function but is also closely related to many systemic dysfunctions, affecting the prognosis of patients with spinal cord injury. Extensive research on the mechanism of skeletal muscle atrophy and intervention at the molecular level has shown that inflammation and oxidative stress injury are the main mechanisms of skeletal muscle atrophy after spinal cord injury and that multiple pathways are involved. These may become targets of future clinical intervention. However, most of the experimental studies are still at the basic research stage and still have some limitations in clinical application, and most of the clinical treatments are focused on rehabilitation training, so how to develop more efficient interventions in clinical treatment still needs to be further explored. Therefore, this review focuses mainly on the mechanisms of skeletal muscle atrophy after spinal cord injury and summarizes the cytokines and signaling pathways associated with skeletal muscle atrophy in recent studies, hoping to provide new therapeutic ideas for future clinical work.
Keywords