Mathematics (Oct 2022)

On the Regulated Nuclear Transport of Incompletely Spliced mRNAs by HIV-Rev Protein: A Minimal Dynamic Model

  • Jeffrey J. Ishizuka,
  • Delaney A. Soble,
  • Tiffany Y. Chang,
  • Enrique Peacock-López

DOI
https://doi.org/10.3390/math10213922
Journal volume & issue
Vol. 10, no. 21
p. 3922

Abstract

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A kinetic model for the HIV-1 Rev protein is developed by drawing upon mechanistic information from the literature to formulate a set of differential equations modeling the behavior of Rev and its various associated factors over time. A set of results demonstrates the possibility of oscillations in the concentration of these factors. Finally, the results are analyzed, and future directions are discussed.

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