Nature Communications (Mar 2022)
Trajectory of immune evasion and cancer progression in hepatocellular carcinoma
- Phuong H. D. Nguyen,
- Martin Wasser,
- Chong Teik Tan,
- Chun Jye Lim,
- Hannah L. H. Lai,
- Justine Jia Wen Seow,
- Ramanuj DasGupta,
- Cheryl Z. J. Phua,
- Siming Ma,
- Jicheng Yang,
- Sheena D/O Suthen,
- Wai Leong Tam,
- Tony K. H. Lim,
- Joe Yeong,
- Wei Qiang Leow,
- Yin Huei Pang,
- Gwyneth Soon,
- Tracy Jiezhen Loh,
- Wei Keat Wan,
- Chung Yip Chan,
- Peng Chung Cheow,
- Han Chong Toh,
- Alfred Kow,
- Yock Young Dan,
- Juinn Huar Kam,
- Shridhar Iyer,
- Krishnakumar Madhavan,
- Alexander Chung,
- Glenn K. Bonney,
- Brian K. P. Goh,
- Naiyang Fu,
- Victor C. Yu,
- Weiwei Zhai,
- Salvatore Albani,
- Pierce K. H. Chow,
- Valerie Chew
Affiliations
- Phuong H. D. Nguyen
- Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre
- Martin Wasser
- Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre
- Chong Teik Tan
- Department of Pharmacy, National University of Singapore
- Chun Jye Lim
- Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre
- Hannah L. H. Lai
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Justine Jia Wen Seow
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Ramanuj DasGupta
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Cheryl Z. J. Phua
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Siming Ma
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Jicheng Yang
- Duke-Nus Medical School
- Sheena D/O Suthen
- Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre
- Wai Leong Tam
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Tony K. H. Lim
- Duke-Nus Medical School
- Joe Yeong
- Duke-Nus Medical School
- Wei Qiang Leow
- Duke-Nus Medical School
- Yin Huei Pang
- Department of Pathology, National University Hospital
- Gwyneth Soon
- Department of Pathology, National University Hospital
- Tracy Jiezhen Loh
- Department of Anatomical Pathology, Singapore General Hospital
- Wei Keat Wan
- Department of Anatomical Pathology, Singapore General Hospital
- Chung Yip Chan
- Duke-Nus Medical School
- Peng Chung Cheow
- Duke-Nus Medical School
- Han Chong Toh
- Duke-Nus Medical School
- Alfred Kow
- Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System
- Yock Young Dan
- Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- Juinn Huar Kam
- Duke-Nus Medical School
- Shridhar Iyer
- Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System
- Krishnakumar Madhavan
- Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System
- Alexander Chung
- Duke-Nus Medical School
- Glenn K. Bonney
- Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System
- Brian K. P. Goh
- Duke-Nus Medical School
- Naiyang Fu
- Duke-Nus Medical School
- Victor C. Yu
- Department of Pharmacy, National University of Singapore
- Weiwei Zhai
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Salvatore Albani
- Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre
- Pierce K. H. Chow
- Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore
- Valerie Chew
- Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre
- DOI
- https://doi.org/10.1038/s41467-022-29122-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
In order to design cancer immune therapies, it is important to understand how tumours evade the immune response that is mounted against them. Authors here analyse the distribution and properties of immune cells in hepatocellular carcinoma and describe a progressive tumour-immune co-evolution programme from early to late stage cancer.
