Research progress on the role of transmembrane proteins in malignant tumors

Abstract

Transmembrane proteins (TMEMs) are a class of family proteins that span lipid bilayers, serving as crucial channel proteins on biological membranes, playing essential physiological roles. TMEMs′ over-expression in malignant tumors, such as TMEM16A and TMEM206, has been linked to the promotion of malignancy. Conversely, down-regulation of TMEM100 expression has been associated with tumor progression. TMEM98, whose expression varies across different malignancies.TMEMs has shown promise as both a therapeutic target and a prognostic marker in cancer.Additionally, TMEMs play a vital role in various malignancies by modulating the Wnt and AKT signaling pathways through interaction with different upstream and downstream regulatory factors. Furthermore, research has provided additional insights into their role in cisplatin-related chemoresistance in specific malignant tumor cell populations.

Keywords

• transmembrane protein|cancer|signaling pathway|chemoresistance