Pharmacokinetics of 99Tc-MDP in Rat Blood

Abstract

In order to investigate the pharmacokinetic characteristics of technetium [99Tc] methylenediphosphonate injection (99TC-MDP) in the blood of rats，the content of 99Tc-MDP in the blood of rats at different time points was directly determined by inductively coupled plasma-mass spectrometry (ICP-MS)，and the drug-time curve was fitted with DAS 2.1.1 software. The main pharmacokinetic parameters were obtained. The results showed that the pharmacokinetic properties of 99Tc-MDP in the blood of rats were consistent with the characteristics of the three-chamber model，and the half-life of the distribution phase T1/2α was 0.047 h，indicating that the drug was rapidly distributed in the body after entering the blood through the tail vein. The elimination phase half-life T1/2β and T1/2γ were 0.113 h and 37.349 h respectively，indicating that the drug was cleared slowly from the body. The results can provide reference for the study of 99Tc-MDP pharmacokinetics in human

Keywords

• 99tc-mdp
• icp-ms
• pharmacokinetics