Choroidal remodeling distribution pattern in the macular region in Chinese young patients with myopia

Abstract

Abstract Background The pathogenesis of myopia has been found to be associated with the blood supply of the choroid. This study aimed to determine the relationship between the distribution pattern of choroidal remodeling and the degree of myopia in young patients. Methods Young patients (age -0.5D, − 0.5 ~ − 3.0D, − 3.01 ~ − 6.0D, and < − 6.0D). Linear regression analysis was applied to assess the association between independent (i.e., age, AL, SE, and intraocular pressure) and dependent variables (i.e., CVI of different regions). Results One hundred sixty-four eyes from 85 volunteers were included. The mean CT in the central foveal was 269.87 ± 63.32 μm (93.00 μm to 443.00 μm). The mean subfoveal-CVI was 67.66 ± 2.40% (57.84 to 79.60%). Multiple linear regression results revealed significant correlations between SE and T1-CVI (p < 0.05, r 2 = 0.082, β = 0.194), N1-CVI (p < 0.05, r 2 = 0.039, β = 0.212). Simple linear regression results revealed that T1-CVI (p < 0.05, r 2 = 0.09) and T3-CVI (p < 0.05, r 2 = 0.05) were negatively correlated with SE; N1-CVI (p < 0.05, r 2 = 0.05) and N3-CVI (p < 0.05, r 2 = 0.04) were negatively correlated with SE. Conclusions CVI in the horizontal meridian underwent the largest change as myopia worsened. Temporal and nasal CVIs within the r = 1 mm, and r = 3 mm subfoveal range were positively associated with the degree of myopia in young patients. The CVI value may be used to assess the vascular status of the choroid and be a potential marker of myopic progression.

Keywords

• Young myopic eyes
• Choroidal vascularity index (CVI)
• Choroidal thickness (CT)
• Spherical equivalent (SE)
• Axial length (AL)